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Gamma Hydroxybutyrate

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If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Gamma-hydroxybutyrate GHB originally was investigated as an anesthetic agent during the s but was abandoned because of side effects including myoclonus and emergence delirium. In , it was approved by the FDA as a treatment for cataplexy and in for excessive daytime sleepiness in patients with narcolepsy. For abuse purposes, GHB is readily available through the illicit drug market and can be made in home laboratories by using recipes posted on the Internet. As a result of increasing abuse, GHB without a legitimate prescription is regulated as a Schedule I substance.
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All three substances are central nervous system depressants with sedative-hypnotic and hallucinogenic properties. Health food stores sold GHB as a dietary supplement after it was synthesized in , before its dangerous, addictive, and even lethal effects came to light. In the s, GHB was popular among body builders, who believed it could release a growth hormone that would stimulate muscle growth. Despite these warnings, GHB continues to be illegally promoted for muscle building, for releasing inhibitions and feeling high, and for combating depression, sleep problems, and weight gain.
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Gamma-Hydroxybutyrate GHB is produced naturally by the body in small quantities, however its exact physiologic function is not known. It can also be manufactured synthetically, which was first done in the s under experimental conditions. It was later classified as a food and dietary supplement and was available for purchase in health food stores in the early s. In , GHB was reclassified by the FDA as a Schedule I controlled substance, meaning that it has a high potential for abuse, has no currently accepted medical use in treatment, and has a lack of accepted safety data supporting the use of the drug under medical supervision. For comparison, examples of other Schedule I drugs include heroin, LSD, marijuana, peyote, and ecstasy.
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